2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128417S2
    D-Glucose-1,6-13C2 287100-67-8 98%
    D-Glucose-1,6-13C2 is the 13C-labeled D-Glucose (HY-B0389). D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.
    D-Glucose-1,6-13C2
  • HY-128417S3
    alpha-D-glucose-d7 23403-54-5 98%
    alpha-D-glucose-d7 is the deuterium labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite.
    alpha-D-glucose-d7
  • HY-128746S1
    2,6-Diaminoheptanedioic acid-15N2 98%
    2,6-Diaminoheptanedioic acid-15N2 is 15N labeled 2,6-Diaminoheptanedioic acid (HY-128746). 2,6-Diaminoheptanedioic acid is an endogenous metabolite.
    2,6-Diaminoheptanedioic acid-15N2
  • HY-128749AR
    D-Glucaric acid tetrahydrate (Standard) 5793-89-5
    D-Glucaric acid tetrahydrate (Standard) (Calcium D-glucarate tetrahydrate (Standard)) is the analytical standard of D-Glucaric acid tetrahydrate (HY-128749A). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp, Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases.
    D-Glucaric acid tetrahydrate (Standard)
  • HY-128753S6
    D-Lyxose-d 288846-88-8 98%
    D-Lyxose-d is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite.
    D-Lyxose-d
  • HY-128753S7
    D-Lyxose-d-1 98%
    D-Lyxose-d-1 is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite.
    D-Lyxose-d-1
  • HY-128790S1
    4-Methoxyestrone-13C6 98%
    4-Methoxyestrone-13C6 is a 13C-labeled 4-Methoxyestrone (HY-128790).
    4-Methoxyestrone-13C6
  • HY-130569S2
    7-Hydroxymethotrexate-d3 ammonium 98%
    7-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d3 ammonium
  • HY-135615AR
    Desmethyl Sibutramine hydrochloride (Standard) 84467-94-7
    Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant.
    Desmethyl Sibutramine hydrochloride (Standard)
  • HY-163263S1
    HSD17B13-IN-80-d2 2770247-90-8 98%
    HSD17B13-IN-80-d2 (Compound 200) is the the deuterium labeled HSD17B13-IN-80 (HY-163263). HSD17B13-IN-80 is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-80 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI).
    HSD17B13-IN-80-d2
  • HY-32351AS1
    Calcifediol-13C5 monohydrate 98%
    Calcifediol-13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-13C5 monohydrate
  • HY-A0132S11
    N-Acetyl-D-glucosamine-13C,15N-1 98%
    N-Acetyl-D-glucosamine-13C,15N-1 is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc.
    N-Acetyl-D-glucosamine-13C,15N-1
  • HY-A0132S12
    N-Acetyl-D-glucosamine-13C6 1194446-34-8 98%
    N-Acetyl-D-glucosamine-13C6 (N-Acetyl-2-amino-2-deoxy-D-glucose-13C6) is the 13C labled N-Acetyl-D-glucosamine (HY-A0132). N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.
    N-Acetyl-D-glucosamine-13C6
  • HY-B0141AS1
    Alpha-Estradiol-d2 81586-94-9 ≥99.0%
    Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
    Alpha-Estradiol-d2
  • HY-B0228S12
    Adenosine-d13
    Adenosine-d13 (Adenine riboside-d13; D-Adenosine-d13) is deuterium labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-d13
  • HY-B0389S11
    D-Glucose-13C-1 84270-10-0 99.90%
    D-Glucose-13C-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-13C-1
  • HY-B0389S12
    D-Glucose-13C-2 120388-24-1 98%
    D-Glucose-13C-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
    D-Glucose-13C-2
  • HY-B0389S17
    D-Glucose-13C-5 106032-62-6 98%
    D-Glucose-13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-13C-5
  • HY-B0389S18
    D-Glucose-13C3-1 478529-32-7 98%
    D-Glucose-13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-13C3-1
  • HY-B0389S19
    D-Glucose-13C,d 201136-45-0 98%
    D-Glucose-13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign
    D-Glucose-13C,d
Cat. No. Product Name / Synonyms Application Reactivity